hyperalgesia
Conditions
Interventions
High-dose remifentanil group:Intraoperatively, remifentanil was infused continuously at a rate of 0.3 µg/(kg-min) and discontinued at the end of the sutured skin,20 mL of saline was pumped for 30 minu
Gradual withdraw of high dose remifentanil:The intraoperative infusion of remifentanil was continued at a rate of 0.3 µg/(kg-min), adjusted to 0.2 µg/(kg-min) 30 min before the expected end of the pro
High dose remifentanil plus post-operative pumping group:Intraoperatively, remifentanil was infused continuously at a rate of 0.3 µg/(kg-min) and stopped at the end of the sutured skin. 1ug/kg of remi
Gradual withdraw of high dose remifentanil plus post-operative pumping group:The intraoperative infusion of remifentanil was continued at a rate of 0.3 µg/(kg-min), which was adjusted to 0.2 µg/(kg-mi
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. patients undergoing elective laparoscopic total hysterectomy for gynaecological conditions 2. age 18 ~ 65 years; 3. ASA class I-II; 4. BMI 18-30 kg/m2; 5. voluntarily participated in the trial and signed the informed consent form
Exclusion criteria
Exclusion criteria: 1. the presence of contraindications to surgery or anaesthesia 2. the presence of allergy to or contraindication to the use of remifentanil 3. the presence of a history of neuropsychiatric disorders, drug and alcohol abuse 4. those with a combination of severe cardiovascular, cerebrovascular, gastrointestinal, respiratory, haematological or neurological disorders 5. the use of opioids or other analgesic drugs within 48h prior to surgery 6. those with symptoms associated with peripheral or central neuropathy, a history of chronic pain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mechanical pain thresholds; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score;Restoring quality scores;Wakefulness mania score;Ramsay Sedation Score;Postoperative extubation time;Postoperative awakening time;Time of first post-operative venting;Total post-operative hospital stay; | — |
Countries
China
Contacts
Public ContactFang Gao
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed