major depressive disorder
Conditions
Interventions
rTMS + online CBT:rTMS combined with online cognitive-behavioral therapy
rTMS+ Cognitive correction therapy:rTMS combined with cognitive correction therapy
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: a)Patients diagnosed with major depressive disorder in Mini-International Neuropsychiatric Interview (MINI Chinese) were eligible for either first episode or relapse. b) Hamilton Depression Scale (HAMD-17) score =14 during the screening and baseline periods; c) Outpatient or inpatient patients aged 18-65 years (including 18 and 65 years), regardless of gender; d) Primary school education or above, able to understand the research content; e) Voluntarily participate in the study and sign the informed consent. f) There was no drug change in the past four weeks, and the type and dose of drug therapy remained unchanged during the study period.
Exclusion criteria
Exclusion criteria: a) MINI Chinese version diagnosed with current/past/lifetime: bipolar disorder, substance abuse, post-traumatic stress disorder, schizophrenia, personality disorder, dissociative conversion disorder, psychosis and other disorders. b) For those at high risk of suicide, the HAMD-17 suicide risk entry is greater than or equal to 3 points. c) mental retardation, dementia and other cognitive disorders. d) Serious physical diseases, brain organic diseases, neurological diseases, etc. e) Presence of a metallic foreign body above the chest. f) received systemic modified electroconvulsive therapy (MECT) or transcranial magnetic stimulation therapy (TMS), deep brain stimulation therapy (DBS), or deviant nerve stimulation therapy (VNS) in the 3 months prior to screening g) Persons currently undergoing psychotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17;functional near-infrared spectroscopy;functional magnetic resonance imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| PHQ-9;CGI-S; | — |
Countries
China
Contacts
Public ContactHongru Zhu
West China Hospital of Sichuan University
Outcome results
None listed