Crohn's disease
Conditions
Interventions
Crohn's disease patients:none
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) The included patients were in line with Chinese consensus on diagnosis and treatment of inflammatory bowel disease(Beijing, 2018). (2) Patients with CD who had been treated with IFX at least once. (3) Complete clinical data such as medical history and auxiliary examination of patients with CD. (4)18-60 years old.
Exclusion criteria
Exclusion criteria: (1) Patients with active infection, radiation enteritis, bacillary dysentery or transient colitis of unknown cause, tuberculosis of the intestine or a history of tuberculosis, who cannot guarantee that they have received a full course of anti-tuberculosis therapy, and a history of colorectal malignancy. (2) Chronic diseases complicated with inflammation, such as congestive heart failure, cirrhosis, renal failure, etc. (3) Use of anti-TNF-a drugs other than IFX or other types of biologics. (4) Patients using IFX for the first time. (5) Pregnant or lactating women. (6) IFX valley concentration and ATIs patients were not detected or refused to be detected. (7) Patients with incomplete clinical and follow-up data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anti-Infliximab antibodies;Infliximab trough concentration ; | — |
Secondary
| Measure | Time frame |
|---|---|
| CRP;ESR;PLT;ALB;Fecal calcaretin; | — |
Countries
China
Contacts
Public ContactTian Jing
Department of Pharmacy,Shanghai Changhai Hospital
Outcome results
None listed