Preoperative Anxiety
Conditions
Interventions
Control group:Routine perioperative anesthesia management
Esketamine group: Anesthesia induction: esketamine 0.5mg/kg intravenously. Intraoperative maintenance: esketamine 0.25mg/(kg*h) intravenous pumping. Postoperative analgesia: PCIA-esketamine 0.15mg/kg
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Expected patients undergoing gynecological surgery under laparoscopy; 2) ASA grading I to II; 3) Patients aged 18-75 years old; 4) No communication barriers, clear consciousness; 5) Voluntary signing of informed consent form
Exclusion criteria
Exclusion criteria: 1) Individuals with severe hypertension or cardiovascular disease; 2) Patients with pulmonary hypertension, intracranial pressure, or high intraocular pressure 3) History of chronic pain; 4) History of mental illness, central nervous system injury; 5) History of psychotropic drug use or alcohol abuse; 6) Severe liver and kidney dysfunction; 7) Communication barriers;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| self-rating anxiety scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-1ß;visual analogue scale score(VAS);Sleep quality;Postoperative nausea and vomiting;IL-6;TNF-a; | — |
Countries
China
Contacts
Public ContactLiwei Wang
Xuzhou Central Hospital
Outcome results
None listed