migraine
Conditions
Interventions
Chinese medicine group:Sanpian Decoction Granules + Sibeline Simulator
Western medicine group:Sibiling Capsules + Sanpian Decoction Granule Simulator
Placement control group: Sanpian Decoction Granule Simulator + Sibeline Capsule Simulator
Sponsors
Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Comply with ICHD-3 unprepared signs and aura migraine diagnosis standards; (2) Compliance with Chinese medicine head wind disease and/or phlegm syndrome, and/or depression, and/or blood stasis diagnosis standards; (3) Age 18-65 years old; (4) The age of the first migraine attack is =50 years; the course of disease is = 1 year; (5) In the past 3 months, the number of headaches every 4 weeks is 2 to 8 times (including 2 and 8 times); (6) Drugs that have not taken migraine for the past 1 month, such as calcium ionic channel blockers, ß -blockers, antidepressants and antiepileptic drugs, etc.; (7) Those who have no abnormalities in the conventional physical examination of the group; (8) Those who can complete the headache diary and sign the consent of informed consent as required.
Exclusion criteria
Exclusion criteria: (1) Those who have headaches caused by the history of head trauma, nervous headache, cluster headache or other organic diseases; (2) Those with long -term analgesic drugs, as well as abuse of alcohol or other drugs; (3) Those who combine liver, kidney, digestion, hematopoietic, cardiovascular system and other serious primary diseases; (4) Participate in other clinical trials at the same time; (5) Women during pregnancy or lactation, or those who are planning to be pregnant within 6 months. (6) Allergic to drugs and its auxiliary materials involved in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| headache diary; | — |
Secondary
| Measure | Time frame |
|---|---|
| Headache Score;TCM Syndrome Points;MSQ;HIT-6;GAD-7;Serum CGRP, 5-HT, PACAP-38, ROS?SOD?TAS?TOS?4-HNE?MDA;IL-1ß?IL-6?IL10?TNF-a;safety outcome;PHQ-9; | — |
Countries
China
Contacts
Public ContactYinglin Cui
Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine)
Outcome results
None listed