lung cancer
Conditions
Interventions
Experimental group:Anesthesia induction: 0.25mg/kg ketamine, intraoperative maintenance: 0.125 mg/(kg·h) ketamine
Control group:Anesthesia induction: 0.25mg/kg saline, intraoperative maintenance: 0.125 mg/(kg·h) saline
Sponsors
Affiliated Hospital of Xiashan District, Zhanjiang City, Guangdong Province
Eligibility
Sex/Gender
All
Age
18 Years to 58 Years
Inclusion criteria
Inclusion criteria: (1) Prepare for single lobectomy under thoracoscopy (2) Between 18 and 58 years old (refer to the previous literature, the basic condition of patients at this stage is relatively good, and the risk of anesthesia is relatively small) (3) ASA grading 1-2 level
Exclusion criteria
Exclusion criteria: (1) Known or suspected allergic or contraindicated to various components of research drugs or other opioids (2) Cerebral injury, intracranial injury or patients with intracranial hypertension (3) Pulmonary hypertension (average pulmonary pressure >25mmHg)(4) Use of painkillers during chronic pain, psychiatric drugs (including opioids, NSAIDS, sedatives, antidepressants, etc.), alcohol abuse and addicts(5) Heart failure (New York Heart Association grade > 2), severe arrhythmia, acute myocardial infarction in the past 6 months, no regular antihypertensive treatment or poor blood pressure control (SBP>=160mmHg and/or DBP>=100mmHg) or patients with (SBP<=90mmHg and/or DBP<=60mmHg)(6) There is a history of abnormal neurological function, such as patients with seizures (7) Previous medical history of thoracic surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative lung complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative admission to ICU; | — |
Countries
China
Contacts
Public ContactZhang liangqing
Affiliated Hospital of Xiashan District, Zhanjiang City, Guangdong Province
Outcome results
None listed