PCOS
Conditions
Interventions
Intervention group:8-hour Time-restricted eating for 12weeks
Sponsors
Women’s Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: [1] Female aged 20-40 [2] Women diagnosed with PCOS according to Rotterdam criteria [3] Combined with insulin resistance [4] 18.5 kg/?=BMI < 24kg/? [5] Can adhere to regular outpatient follow-up [6] Sign the informed consent voluntarily and be willing to participate in this study
Exclusion criteria
Exclusion criteria: [1] received Weight-loss therapy including professional diet and exercise management, bariatric surgery or taking drugs in the past 3 months [2] The weight change in the past 3 months was more than 5% [3] Fasting for more than 16 hours a day [4] Currently taking oral contraceptives, glucocorticoid drugs, insulin sensitizers, metformin and other drugs that affect glucose metabolism [5] suffering from diabetes, hypertension, cardiovascular disease and others requiring regular medication for a long time [6] Severe hepatic and renal insufficiency [7] mental illness that requires medication [8] More than 100 grams of alcohol per week ( Volume * concentration *0.8) [9] Smoking [10] =1 night shift per week [11] abortion history in the last 3 months [12]Being pregnant [13] Participating in other interventional studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HOMA-IR (Homeostasis model assessment-insulin resistance); | — |
Secondary
| Measure | Time frame |
|---|---|
| serum glucose;serum insulin;triglyceride;cholesterol;High-density lipoprotein;Low-density lipoprotein;estradiol;progesterone;Follicle stimulating hormone;Luteinizing hormone;Total testosterone;prolactin;Dehydroepiandrosterone sulfate;Sex hormone binding globulin;weight;blood pressure;Waist-hip ratio;score of SF-36;score of Three-Factor-Eating-Questionnaire-R21;score of The Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire ;score of Appetite VAS;score of Self-Rating Anxiety Scale;score of Self-rating Depression Scale; | — |
Countries
China
Contacts
Public ContactZhang Dan
Women’s Hospital, Zhejiang University School of Medicine
Outcome results
None listed