postoperative cognitive dysfunction, POCD
Conditions
Interventions
insulin group (group I):Starting two days before surgery, insulin nasal drops should be administered twice a day until the day of surgery, 20U each time (0.5 ml)
control group (group C):Starting two days before surgery, physiological saline nasal drops of 0.5 ml were administered twice a day until the day of surgery
Sponsors
Department of Anesthesia, Beijing Luhe Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: elderly patients of either sex, aged = 65 years, BMI = 25 kg/m 2, ASA grade I to III undergoing elective laparoscopic radical resection of colorectal cancer under general anesthesia
Exclusion criteria
Exclusion criteria: History of diabetes, insulin allergy, neurological history, psychiatric history or communication difficulties, Mini-Mental State Examination (MMSE) score < 23, and uncooperative with the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum IL-1 concentrations ;serum IL-6 concentrations ;serum S100ß concentrations; | — |
Countries
China
Contacts
Public ContactHai-long Zhang
Department of Anesthesia, Beijing Luhe Hospital Affiliated to Capital Medical University
Outcome results
None listed