traumatic spinal cord injury
Conditions
Interventions
mitigation group G1:none
unmitigated group G2:none
Sponsors
China Rehabilitation Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) All patients had traumatic spinal cord injuries due to trauma and were 18-60 years old; (2) The site of damage was cervical or thoracolumbar; (3) They were in the subacute (48h-14d) and intermediate (14d-6 months) phases as defined in the Clinical Treatment Guidelines for Neurorestoration of Spinal Cord Injury (2021 edition); (4) Entered our hospital for treatment no more than 1 month after surgery; (5) Those whose MRI imaging suggests support for the diagnosis and excludes craniocerebral injury; (6) Those with severe disc herniation and/or previous spinal surgery are excluded; (7) Those who do not have significant organ damage such as heart or kidney damage; (8) Those who have no past history of Alzheimer's disease, no mental disorder, consciousness disorder, and language disorder, ideal cooperation, and good communication skills; (9) All patients signed an informed consent form, which was discussed and approved by the Ethics Committee.
Exclusion criteria
Exclusion criteria: (1) With severe malignant lesions, hematopoietic and coagulopathic disorders, immune system diseases; (2) Pregnant or lactating women; (3) People with hypertension, diabetes, or abnormal liver or kidney functions (4) Patients who have not used hormones and other immune agents before the test; (5) Patients with complications such as heterotopic ossification that cause elevated inflammatory indicators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the expression levels of IFN-? and CCL2/MPC-1;ASIA scale scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| SCIM scale scores; | — |
Countries
China
Contacts
Public ContactLi Jun
China Rehabilitation Research Center,Beijing Boai Hospital
Outcome results
None listed