Regulation mechanisms of non-coding RNAs in inflammatory response of chronic obstructive pulmonary disease

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300074401

Enrollment

Unknown

Registered

2023-08-06

Start date

2023-08-01

Completion date

Unknown

Last updated

2023-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

Healthy smokers:None

COPD:None

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Voluntarily participating in the study, understanding and signing the informed consent. 2, Aged between 40 and 80 years old. 3. COPD patients: smoking =10 pack-years, with a history of COPD diagnozed by pulmonary function test, or recent pulmonary function test indicating that FEV1 / FVC < 0.7, after inhaling bronchodilators. 4. Control participants: with a history of smoking but not COPD, or recent pulmonary function test indicating that FEV1 / FVC=0.7 after inhaling bronchodilators.

Exclusion criteria

Exclusion criteria: 1. Patients with acute diseases (including acute infectious diseases) or experiencing acute phase of chronic diseases 2. Patients with unstable cardiovascular disease 3. Patients with diabetes 4. Patients with liver and kidney diseases 5. Patients with autoimmune disease 6. Patients with malignant tumors 7. Patients with neuropsychiatric disorders 8. Patients with other lung diseases

Design outcomes

Primary

Measure	Time frame
non-coding RNAs in peripheral blood mononuclear cells;	—

Secondary

Measure	Time frame
Pulmonary function;	—

Countries

China

Contacts

Public ContactLei Chen

West China hospital of Sichuan university

lchens@126.com+86 189 8060 6220

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026