Aortic dissection
Conditions
Interventions
Test group :The test group were Stanford type A dissection patients who received ketorolac drug treatment. Before the operation, ketorolac was intramuscularly injected 60mg, and after the operation, 3
control group:The control group were Stanford type A dissection patients who received placebo drug treatment. Before the operation, the same dose, same dosage form and same time of placebo glucose int
Sponsors
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Type A Aortic dissection patients confirmed by imaging and planning emergency surgery; 2. Between the ages of 18 and 65; 3. Sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Long term fasting or inability to self eat; 2. History of malignant tumors; 3. Weight<50kg; 4. Traumatic Aortic dissection; 5. Patients with Marfan syndrome; 6. Unstable vital signs require mechanical assistance or rescue before surgery (IABP, ECMO, LVAD Etc.); 7. Patients who need Tracheal intubation before operation; 8. Disorders of consciousness, central nervous system dysfunction and evidence of cerebral hypoperfusion syndrome after admission; 9. Preoperative symptoms of hematemesis, black or bloody stools, and intestinal dilation; 10. There is clear evidence of limb hypoperfusion before surgery; 11. Existence of organ hypoperfusion syndrome; 12. Patients who need to undergo interventional surgery to relieve poor organ perfusion; 13. Have a history of gastrointestinal ulcers or chronic gastrointestinal inflammation; 14. Dialysis before admission or a history of renal insufficiency; 15. Have a history of liver disease; 16. Allergies to ketorolac tromethamine and aspirin or other Nonsteroidal anti-inflammatory drug; 17. Chronic inflammatory diseases, autoimmune diseases, or other reasons require long-term use of hormones or non-Steroid drugs; 18. No cerebral perfusion during deep hypothermic circulatory arrest; 19. Have a history of Grade 4 surgery or acute myocardial infarction within 90 days; 20. Previous heart or Great vessels surgery history; 21. Pregnant and lactating women; 22. Refusing to participate in this clinical trial or sign an informed consent form; 23. Other situations where the researcher deems it unsuitable to participate in this project;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| death;malperfusion;dialysis;coagulation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine examination;Biochemical complete set ;Interleukin-6;Serum B-type natriuretic peptide; | — |
Countries
China
Contacts
Public ContactWang Dongjin
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed