Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Intervention Group:In addition to routine treatment, pulmonary rehabilitation intervention will be conducted. The specific intervention includes exercise training, proper use of inhalers, education on
Control Group:Usual care
Sponsors
Xiamen Branch, Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
40 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) COPD patients aged between 40 and 80 years old. (2) Stable period pulmonary function reports within the past 6 months, showing that after inhaling a bronchodilator (400ug of salbutamol) for 15-30 minutes, the FEV1/FVC ratio is less than 0.70, and the FEV1 is between 30-80% of the predicted value (i.e., GOLD II-III stage). (3) No acute exacerbation events have occurred in the past 14 days (i.e., no events characterized by respiratory difficulties and/or cough, or worsening cough). (4) Residents of Haicang District, Xiamen City. (5) Willing to participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Presence of significant comorbidities other than COPD. *Significant comorbidities are defined as conditions that, in the opinion of the researchers, may put the patient at risk or potentially affect the study results, or significantly impact the patient's ability to participate in the study. Examples include myocardial infarction, stroke, shock, uncontrolled hypertension (systolic blood pressure >160mmHg, diastolic blood pressure >90mmHg), and uncontrolled hyperglycemia within the past 3 months. (2) Presence of musculoskeletal disorders or lower limb mobility impairments that prevent the completion of exercise training. (3) No absolute contraindications to pulmonary function testing. (4) Participation in other clinical trials within the 3 months prior to screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in 2-Minute Stepper Test.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of AECOPD (times/person/year);Time of the first occurrence of acute exacerbation event in chronic obstructive pulmonary disease (COPD);Change in pulmonary function (FEV1, FVC, FEV1/FVC, peak inspiratory flow rate, etc.) from baseline to 8 weeks after intervention.;Area under the FEV1 curve after 8 weeks of intervention;Maximal Inspiratory Pressure, MIP;Change in Modified Medical Research Council (mMRC) scores after 8 weeks of intervention;Change in COPD Assessment Test (CAT) scores after 8 weeks of intervention;Blood Pressure;Life Quality;Drug Adherence; | — |
Countries
China
Contacts
Public ContactPan Zhigang
Zhongshan Hospital, Fudan University; Xiamen Branch, Zhongshan Hospital, Fudan University
Outcome results
None listed