Changes in Pain Perception Following Aerobic Exercises with Different Loads and The Potential Mechanisms of Exercise-induced Hypoalgesia

Modulation of Pain Perception and Tolerance Following Aerobic Exercises with Different Loads

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300074367

Enrollment

Unknown

Registered

2023-08-04

Start date

2023-08-30

Completion date

Unknown

Last updated

2023-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myofascial Pain / Experimental pain test

Interventions

Group A:Running for 30min with 40% HRR

Group B:Running for 30min with 55% HRR

Group C:Running for 30min with 70%

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Healthy individuals (1) had no pain or pain-related syndrome within 3 months; (2) had no injury history of lower extremities within 1 year; (3) had no neurological disability, including anxiety, depression or cognitive impairments; (4) had no potential or confirmed heart disease, or recovered from a heart disease less than 1 year.

Exclusion criteria

Exclusion criteria: (1) failed to maintain or tolerant the exercise intensity during the treadmill running; (2) showed serious exertion or fatigue in 24-48 hours after exercise sessions (RPE scores over 18); (3) showed intolerable pain during the pain perception test or the condition pain modulation (CPM) test.

Design outcomes

Primary

Measure	Time frame
Pressure pain thresholds;Pressure pain tolerance thresholds;Heat pain thresholds;Heat pain tolerance thresholds;	—

Secondary

Measure	Time frame
Conditioned pain modulation;	—

Countries

China

Contacts

Public ContactXU Zihan

School of Sport Medicine and Rehabilitation, Beijing Sport University

2290259311@qq.com+86 178 8883 7585

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026