encephaledema
Conditions
Interventions
group A: Oxygen (33.3%)
group B: Oxygen+hydrogen (less than 2 hours)
group C:Oxygen+hydrogen (2 hours - 4 hours)
group D: Oxygen+hydrogen (more than 4 hours)
Sponsors
Sanbo Brain Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: ? American Association of Anesthesiologists (ASA) grade I or II patients; ? No serious systemic symptoms (such as heart, lung, liver and kidney failure); ? Mini-cog (simple intelligence state assessment form) score 3 points; ? Be able to sign informed consent; ? The anesthesia process is in accordance with the unified anesthesia plan, and the infusion volume is adjusted according to the PPV results, so as to strictly avoid perioperative fluid overload
Exclusion criteria
Exclusion criteria: ? Pregnant and lactating women; ? Mentally or physically disabled patients; ? Have a history of serious heart disease; ? Known intolerance to inhalation therapy; ? It is difficult to attach the electrode because the operation area is too rough, such as after bilateral bone flap removal; ? Other situations that cannot be monitored, such as allergy to electrode patches; ? Malignant encephalocele or other monitoring electrodes will be harmful to the patient's condition; ? Other situations that cannot be monitored
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Course of cerebral edema; | — |
Secondary
| Measure | Time frame |
|---|---|
| Matrix metalloproteinase (MMPs);Syndecan-1(Syn-1);Heparanase(HS);hyaluronic acid(HA);C-reactive protein(CRP);Interleukin-6(IL-6);Tumor necrosis factor(TNF-a); | — |
Countries
China
Contacts
Public ContactBaoguo Wang
Sanbo Brain Hospital Capital Medical University
Outcome results
None listed