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Study on the mechanism of blood flow restriction exercise regulating endothelial progenitor cell function in patients with type 2 diabetes

Blood Flow Restriction Exercise Improving The Function Of Endothelial Progenitor Cells In Patients With Type 2 Diabetes Via Regulation Of TRF2/SIRT3/FOXO3a

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300074357
Enrollment
Unknown
Registered
2023-08-04
Start date
2023-09-01
Completion date
Unknown
Last updated
2023-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Interventions

Control group:Keep the original exercise habits without exercise intervention
BFRE group:12 week BFRE training
Resistance training group:Resistance training for 12 weeks

Sponsors

the Second Affiliated Hospital of Shaoyang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: ? It meets the WHO diagnostic criteria for type 2 diabetes in1999: Based on oral glucose tolerance test (OGTT), fasting plasma glucose (FPG) = 7.0mmol/l and / or two-hour postprandial blood glucose (2-h post load plasma glucose, 2-hpg) = 11.1mmol/l, or random blood glucose = 11.1mmol/l; ? Age: 40-70 years old; ? A sedentary lifestyle; ? Those who have completed the pre exercise assessment and have no movement disorder or contraindication; ? BMI is between 24kg/m2-30kg/m2; ? During the study period, it is required to take hypoglycemic and lipid-lowering drugs or inject insulin in strict accordance with the doctor's advice, and it is not allowed to change it without permission; ? Informed consent and voluntary participation; ? Those who have not received other research interventions and meet the above criteria can be included in this study.

Exclusion criteria

Exclusion criteria: ? Those in the state of infection stress have various uncontrolled or serious acute and chronic diseases, psychoses, tumors and other immune diseases; ? A history of alcohol abuse in the past year; ? Those who refuse to participate or fail to cooperate in completing the study as required; Those meeting any of the above conditions shall be excluded.

Design outcomes

Primary

MeasureTime frame
Blood glucose;blood lipids;Blood pressure;Endothelial progenitor cells;ROS;telomere repeat-binding factor 2;Forkhead box class O3a;Sirtuin 3;

Secondary

MeasureTime frame
Insulin;Height;Weight;Waist;

Countries

China

Contacts

Public ContactMa Xiaojun

Shaoyang University

821080836@qq.com+86 739 543 5003

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026