AIDS with depressive symptoms
Conditions
Interventions
Treatment group:ART conventional treatment and transcutaneous auricular vagus nerve stimulation
Control group:ART conventional treatment and transcutaneous non-vagus nerve stimulation
Sponsors
Institute of acupuncture and moxibustion, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria; 2. Being HIV positive and confirmed by a Western Blot report confirmatory test; 3. Patients aged between 18-70 years, male or female; 4. 24 >= points >= 7 on the 17-item Hamilton Depression Scale (17-HAMD); suicidal ideation excluded, with all responses on the Suicide Severity Scale being "no" and a score of < 3 on item 3 of the HAMD-17 (suicide item); 5. On ART for more than 2 years, with a plasma HIV load of less than 50 copies/ml for more than 1.5 years; 6. CD4+ T lymphocyte level < 200 cells/ul or an increase of < 20% compared to treatment baseline; 7. Patients voluntarily sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with severe opportunistic infections that were not controlled prior to enrollment; 2.Patients who were enrolled in a clinical trial of another drug within 1 month prior to enrollment or are currently enrolled in a clinical trial of another drug; patients who have met DSM-V criteria for substance-related and addictive disorders within the past 6 months; 3. Patients who were receiving any other antidepressant medication prior to enrolment; 4. WBC = 2 times the upper limit of the reference value, abnormal renal function means creatinine clearance below normal); 5. Patients with a history of schizophrenia or other psychiatric disorders; patients with cognitive impairment or personality disorders; 6. Women who are pregnant or breastfeeding, or planning to become pregnant; 7. In combination with other serious diseases (e.g. tumours, cirrhosis of the liver, cardiovascular disease, etc.); 8. Patients with an intellectual or language impairment that prevents them from fully understanding the test or cooperating well. Those who meet the inclusion criteria but have one of the above conditions will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 17-HAMD (Hamilton Depression Rating Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| 14-HAMA (Hamilton Anxiety Scale);WHO-HIV Quality of Survival Scale score;Heart rate variability(HRV); | — |
Countries
China
Contacts
Public ContactLi Shaoyuan
Institute of acupuncture and moxibustion, China Academy of Chinese Medical Sciences
Outcome results
None listed