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Efficacy of different doses of Ondansetron alone or combined with other antiemetic agents in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)

Efficacy of different doses of Ondansetron alone or combined with other antiemetic agents in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300074302
Enrollment
Unknown
Registered
2023-08-03
Start date
2023-08-03
Completion date
Unknown
Last updated
2023-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chemotherapy-induced nausea and vomiting

Interventions

CINV group:ondansetron

Sponsors

Tongren Hospital, Shanghai Jiao Tong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: (1) Age =18 years old; (2) The patient received ondansetron between January 1, 2021 and December 31, 2022; (3) Malignant tumor was confirmed by histopathology or cytology, regardless of tumor type, TNM stage and previous chemotherapy.

Exclusion criteria

Exclusion criteria: (1) Patients with nausea and vomiting and other symptoms 1 week before enrollment; (2) Patients allergic to 5-HT3 receptor antagonists, dexamethasone and NK-1 receptor antagonists; (3) patients who are taking opioids; (4) suffering from central nervous system disease or mental system disease; (5) Patients with active infection or severe complications; (6) Pregnant or lactating population.

Design outcomes

Primary

MeasureTime frame
complete response rate;complete control rate;overall response rate;

Secondary

MeasureTime frame
The incidence of nausea and vomiting in different CINV types;Nausea and vomiting grading;

Countries

China

Contacts

Public ContactJianjun Zhang

Tongren Hospital, Shanghai Jiao Tong University School of Medicine

robustzhang168@aliyun.com+86 18930172901

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026