Upper limb surgery under brachial plexus block
Conditions
Interventions
Experimental group:The method of the remimazolam's loading dose measurement: initial loading dose of remimazolam was 4 mg.kg-1.h-1, and the intravenous pump was injected for 1 min, the gradient dose o
otherwise, sedation was unsatisfactory. If sedation was satisfactory, respiratory depression or severe drop in blood pressure occurred after administration, the next patient was reduced by one gradien
Sponsors
Yanan University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-64 years old; 2) American Society of Anesthesiologists (ASA) Levels I ~ III; 3) Body mass index (BMI) 18-30 kg/m2; 4) Patients with upper limb surgery under brachial plexus block; 5) The subjects or their family members sign the informed consent for the study.
Exclusion criteria
Exclusion criteria: 1) Those who suffer from mental illness or cognitive dysfunction and cannot communicate normally; 2) Those who have contraindications or allergies to the tested drugs; 3) Severe hypertension (SBP=180 mmHg or DBP=110 mmHg), diabetes, heart disease, arrhythmia; 4) Hemodynamic instability (hypotension, i.e., SBP 100 beats/min); 6) Use sedation, hypnosis, anti-anxiety, antidepressant drugs in 1 month; 7) Those assessed as having difficult airway; 8) Hypoxemia caused by various reasons (SpO2 < 90%); 9) Participants in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time from the beginning of remimazolam loading dose to the satisfied sedation ;Severe hypotension ;Respiratory depression;Recovery time;MOAA/S score;Whether satisfited sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| BIS;Vital sign; | — |
Countries
China
Contacts
Public ContactGao Hui
Yanan University Affiliated Hospital
Outcome results
None listed