Carotid endarterectomy in patients with coronary artery disease
Conditions
Interventions
Test group 1:ciprofol 0.3 mg/kg for induction of general anesthesia
Test group 2:ciprofol 0.4 mg/kg for induction of general anesthesia
Control group:Propofol 2.0mg/kg for general anesthesia induction
Sponsors
General Hospital of the Northern War Zone of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age >18 years, regardless of gender; 2) Stenosis of more than 1 coronary artery vessel confirmed by coronary artery-related tests (coronary angiography or coronary CT) narrowing of >50%; (3) unilateral carotid artery stenosis of 70% to 99% or unilateral carotid artery stenosis of 50% to 69% with clinical symptoms. (4) American Society of Anesthesiologists (ASA) classification of I-III; (5) cardiac function (NYHA) class I-III; 6) BMI of 18-30 kg/m2; 7) complete perioperative information; 8) voluntary signed informed consent;
Exclusion criteria
Exclusion criteria: 1) Known hypersensitivity to the active ingredients or excipients of ciprofol or propofol injection 2) Combination of other cardiac diseases ( congenital heart disease, rheumatic heart disease, pulmonary heart disease, cardiomyopathy, valvular disease, etc.); 3) non-atherosclerotic carotid stenosis such as fibromuscular dysplasia, aortitis, carotid body aneurysm; 4) those with previous CEA or carotid artery stenting (carotid artery stenting, CAS); 5) Patients with difficult airways, patients with modified Mallampati classification grade IV; 6) Patients who are pregnant or breastfeeding; patients with planned pregnancy within 1 month after surgery 7) moderate to severe hepatic impairment or concomitant hepatic enzyme induction/inhibitors (including within 2 weeks of discontinuation); renal dysfunction (blood creatinine >177 µmol/L); 8) Patients with severe impairment of consciousness or presence of psychiatric system disorders (schizophrenia, mania, bipolar abnormalities, psychosis, etc.) and cognitive dysfunction; 9) previous hematologic disorders, malignant tumors; 10) chronic substance abusers, patients with a history of sedative/narcotic drug use within 1 month 11) Patients with significantly abnormal preoperative physical examination or laboratory test results;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| area under baseline of mean arterial pressure after administration; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;systolic blood pressure;diastolic blood pressure;cardiac index;stroke volume variation ;systemic vascular resistance index;successful induction rate of general anesthesia;time to successful induction of general anesthesia;change in cerebral oxygen saturation;change in bispectral index value; | — |
Countries
China
Contacts
Public ContactQiang Jin
General Hospital of the Northern War Zone of the Chinese People's Liberation Army
Outcome results
None listed