Genicular nerves block vs. local infiltration analgesia combined with adductor block in total knee arthroplasty patients: a randomised controlled non-inferiority trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300074274

Enrollment

Unknown

Registered

2023-08-02

Start date

2023-08-10

Completion date

Unknown

Last updated

2023-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

total knee arthroplasty

Interventions

Group GA:The five knee nerves were given 0.2% ropivacaine 4ml, respectively+ 0.33% ropivacaine 20ml at the proximal adductor canal

Group LA:0.2% ropivacaine 80ml plus 10ug/ml epinephrine for local infiltration analgesia of knee joint + 0.33% ropivacaine 20ml at the proximal adductor canal

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: ? Patients requiring unilateral total knee arthroplasty who voluntarily participated in the study and signed informed consent;? Age 18-75 years old, gender is not limited; ? American Society of Anesthesiologists (ASA) Grade I-III; ?Body mass index (BMI) 18-40 kg/m2.

Exclusion criteria

Exclusion criteria: ? Allergic to opioids and amides; ? Past history of neurological disease or abnormal coagulation function; ? Patients with previous knee surgery history; Long-term use of opioids or severe alcohol abuse; ? People with mental cognitive disabilities; ? Those who refuse to participate or ask to quit midway.

Design outcomes

Primary

Measure	Time frame
Rest VAS score at 24h ;	—

Secondary

Measure	Time frame
Rest and exercise VAS scores at other time points after surgery;quadriceps strength at each time point after operation;knee active range of motion (ROM) at each time point after operation;Intraoperative opioid consumption and postoperative opioid consumption for 24 hours;the leaving bed time;hospital stay;Time of first request for remedial analgesia;Incidence of postoperative nausea and vomiting;time to perform the blocks;	—

Measure

Time frame

Rest and exercise VAS scores at other time points after surgery;quadriceps strength at each time point after operation;knee active range of motion (ROM) at each time point after operation;Intraoperative opioid consumption and postoperative opioid consumption for 24 hours;the leaving bed time;hospital stay;Time of first request for remedial analgesia;Incidence of postoperative nausea and vomiting;time to perform the blocks;

—

Countries

China

Contacts

Public ContactLiu Danyan

The First Affiliated Hospital of Chongqing Medical University

Liudanyan418@qq.com+86 139 8391 6178

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026