Severe diseases in Neurosurgery
Conditions
Interventions
case series:none
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18-70 years old; (2) Inpatient with clinical diagnosis of traumatic brain injury, cerebral hemorrhage or subarachnoid hemorrhage, and the onset time is within 72 hours; (3) Using mechanical ventilation to support; (4) APACHE II score = 15 points, and expected ICU hospitalization time = 3 days; (5) Obtaining informed consent from patients or family members
Exclusion criteria
Exclusion criteria: (1) Shock or unstable vital signs; (2) Severe heart, lung, liver, or kidney dysfunction; (3) Unable to cooperate with muscle ultrasound examination; (4) Pregnant patients; (5) Recently participated in other clinical trials; (6) Patients with a previous history of muscular atrophy, including myogenic atrophy (such as congenital myopathy, muscular dystrophy, etc.) and neurogenic atrophy (such as amyotrophic lateral sclerosis/Motor neuron disease, spinal muscular atrophy, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| duration of mechanical ventilation ;Rectus femoris muscle thickness;The biceps brachii muscle thickness;Rectus femoris cross sectional area;The biceps brachii cross sectional area; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day infection rate;60-day mortality;60-day GOSE score;length of ICU stay;length of hospital-stay;Duration from admission to death;GCS score at ICU admission;SOFA score at ICU admission;APACHE II score at ICU admission;NRS2002 score at ICU admission;mNUTRIC score at ICU admission;Rectus femoris echo intensity;The biceps brachii echo intensity;Calf circumference;C-reactive protein;procalcitonin;Sarcopenia index ;hemoglobin;albumin;prealbumin;retinol-binding protein; | — |
Countries
China
Contacts
Public ContactXi Caihua
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed