Clinical effect of single adductor canal block with bupivacaine liposomal on postoperative analgesia after total knee arthroplasty

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300074254

Enrollment

Unknown

Registered

2023-08-02

Start date

2023-10-09

Completion date

Unknown

Last updated

2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative analgesia after total knee arthroplasy

Interventions

Experimental group:Before anesthesia, the patient underwent ultrasound-guided adductor canal block using bupivacaine liposomal suspension at a dose of 133mg/15ml. Routine cocktail infiltration during

Control group 1:Before anesthesia, the patient underwent ultrasound-guided adductor canal block using 15ml of 0.3% ropivacaine injection. Routine cocktail infiltration during surgery.

Control group 2:The patient underwent LIA treatment during surgery, and the surgeon injected 50ml of a mixed injection preparation of 0.4% ropivacaine 20ml, hydromorphone 2mg, tranexamic acid 1g, and

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Patients undergoing primary unilateral knee joint arthroplastic with single spinal anethesia; 2.Patients aged >=18 years; 3.Patients classified as I-III by the American Society of Anesthesiologists (ASA); 4.Body Mass Index (BMI) between 18 and 30 kg/m^2.

Exclusion criteria

Exclusion criteria: 1. Patients who did not obtain informed consent; 2. Patients with infection at the puncture site; 3. Patients with abnormal coagulation function; 4. Patients who are allergic to local anesthetics; 5. Individuals with mental illness or who have been using psychotropic drugs for a long time; 6. Patients with Mini-Mental State Examination (MMSE) scores below 24; 7. Patients who have adjusted the anesthesia method during surgery; 8. Patients those assessed by anesthesiologists as having contraindications for surgical anesthesia.

Design outcomes

Primary

Measure	Time frame
Postoperative 24-hour static pain score and Postoperative 24-hour dynamic pain score;Morphine equivalent (Total consumption of opioid drugs);	—

Secondary

Measure	Time frame
The range of motion (ROM) of the knee joint;Quadriceps muscle strength;First out-of-bed mobilization and 72-hour postoperative walking distance;Postoperative complications;Length of hospital stay;Participants satisfaction;Cortisol;Blood glucose levels;	—

Countries

China

Contacts

Public ContactWen Jiajun

Shunde Hospital of Guangzhou University of Chinese Medicine

myra2018@126.com+86 137 2633 3103

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026