The relationship between microbial tryptophan metabolites and atherosclerosis

Lactobacillus rhamnosus ameliorates atherosclerosis by modulating oxidative stress via tryptophan metabolites

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300074224

Enrollment

Unknown

Registered

2023-08-01

Start date

2023-08-01

Completion date

Unknown

Last updated

2023-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary heart disease

Interventions

CHD1 group:none

Control group:none

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Coronary artery disease(CHD) group: those who are between 40 and 70 years of age and had coronary stenosis greater than 50% as suggested by coronary CT or coronary angiography. 2.Control group: those who excluded coronary artery disease by history, electrocardiogram, coronary CT or coronary angiography. Sex, age, and cardiovascular risk factors were matched to the CHD group.

Exclusion criteria

Exclusion criteria: Infectious diseases, hereditary diseases, autoimmune-mediated metabolic diseases; digestive diseases (inflammatory bowel disease, acute/chronic diarrhea, chronic constipation); severe cardiac, hepatic, and renal insufficiency; chronic respiratory diseases (COPD, asthma, etc.); taking antibiotics, prebiotics or probiotics, and proton-pump inhibitors for more than 3 days in the past 1 month.

Design outcomes

Primary

Measure	Time frame
Plasma IAA;Monocytes in PBMC;	—

Countries

China

Contacts

Public ContactLiu Yajuan

General Hospital of Ningxia Medical University

liuyajuan528@163.com+86 138 9549 3123

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026