Rectal mucosal lesions and submucosal tumors expected to be resectable under endoscopy
Conditions
Interventions
Group interventon:Close the rectal defects after ESD with or without myectomy using the strategy combining EHS with clips (EHS-Clips)
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Endoscopic evaluation of feasible endoscopic submucosal dissection (ESD) with or without myectomy for rectal lesions. 2. The estimated size of the specimen is <= 50mm. 3.18 years <= age <= 80 years. 4.The ECOG score is 0-1 points.
Exclusion criteria
Exclusion criteria: 1.Lesions with lymph node metastasis. 2. Patients with poor general condition and inability to tolerate endoscopic surgery. 3.Patients with coagulation dysfunction (platelet count 2) or taking antithrombotic agents, before their coagulation function is corrected. 4. Patients who refuse or are not suitable for surgery. 5. Patients with previous abdominal or pelvic radiation therapy. 6. The 'lifting sign' is negative. 7. Some researchers believe that patients with other clinical and laboratory conditions should not participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete closure rate of postoperative defects;Delayed postoperative bleeding rate;Continuous closure rate of postoperative defects; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding rate during EHS;Perforation rate during EHS;EHS time;Postoperative delayed perforation rate;Incidence of other postoperative adverse events; | — |
Countries
China
Contacts
Public ContactGuiqi Wang
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed