Disorder of consciousness
Conditions
Interventions
Patient control group:placebo
Patient intervention group:FAST scheme
Healthy control group:placebo
Healthy people intervention group:FAST scheme
Sponsors
China Rehabilitation Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: patient (1) Patients meeting the European Society of Neurology guideline PDOC criteria (more than 4 weeks after brain injury). (2) UVS/VS or MCS were diagnosed after 5 CRS-R assessments within 1 week (3) The cause was clear and the vital signs were stable (4) MMN amplitude of auditory evoked potential test was >0.6µV and <3µV; (5) Age 18-75 years old (6) Right-handed (7) Have not participated in other clinical studies in the past 3 months (8) Sign an informed consent form signed by a family member or authorized person Healthy person (1) Match the age of the patient, between 18 and 75 years old, regardless of gender; (2) Good health, no circulatory system, nervous system, mental and metabolic disorders and other diseases; (3) having full capacity for civil conduct; (4) The subject voluntarily signs the informed consent.
Exclusion criteria
Exclusion criteria: patient (1) The patient's condition is unstable, respiratory or circulatory system complications are serious and uncontrolled, acute stage of onset, epileptic state, multiple trauma, limb fracture, and large skin defect; The disease continued to worsen, active cerebral hemorrhage has not been controlled. (2) Suffering from mental illness, drug or chronic alcohol addiction. (3) Intracranial metal objects, intracranial tumors, intracranial infections, or the presence of any clinically significant or unstable medical disease (4) Infection (5) Defective or abnormal head, unable to collect fNIRS data (6) People with severe hearing impairment (7) Have high musical literacy, or have been engaged in music related work; Healthy people: (1) Previous history of atrial fibrillation, heart surgery or betaloc; (2) a history of mental illness, drug abuse, or drug dependence; (3) Pregnancy test positive or breastfeeding women. (4) Excessive consumption (more than 8 cups per day, 250mL per cup) of tea, coffee or caffeinated beverages in the past 6 months; Had consumed any beverage or food containing caffeine (such as coffee, strong tea, chocolate, etc.) within 48 hours before the trial began; (5) Defective or abnormal head, unable to collect fNIRS data (6) having hearing impairment; (7) Have high musical literacy, or have been engaged in music related work;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GCS Score;CRS-R Score;fNIRS relevant data; | — |
Countries
China
Contacts
Public ContactJinqin Zhang
China Rehabilitation Research Center
Outcome results
None listed