Acute myocardial infarction
Conditions
Interventions
Trial group:Evolocumab and standard treatment
Control group:Standard treatment
Sponsors
The First Affiliated Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age =18 years and =80 years old (2) Completion of coronary angiography within 24 h (72 h for NSTEMI) of the onset of typical symptoms, electrocardiograms, or myocardial enzyme profiles. (3) The diagnosis of ASCVD-related myocardial infarction is clear from coronary angiography, and immediate PCI is required. (4) Patients gave informed consent, participated in the study voluntarily and signed an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Unable to complete the follow-up (including but not limited to Killip grade IV or other basic clinical instability as judged by the investigator, patient's inability to co-operate, or combination of other serious diseases, etc.). (2) Contraindication to the use of PCSK9 inhibitors (severe allergies, etc.). (3) Previous application of any type of PCSK9 inhibitor (4) Clearly statin intolerant people (5) Allergic reaction immediately after coronary angiography (6) Recent application (within 3 months) of other biologics, immunosuppressants, immunomodulators, antimetabolite drugs. (7) Dialysis treatment status (8) Combined active malignant tumours, immune system diseases requiring treatment, serious infections and other diseases that may affect the prognosis (9) Women who are planning to become pregnant or are pregnant or breastfeeding. (10) Enrolled in other clinical trials that may affect the purpose or outcome of the study. (11) Other conditions that the investigator considers inappropriate for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid levels;Rate of lipoprotein(a) decline ; | — |
Secondary
| Measure | Time frame |
|---|---|
| NT-proBNP;Inflammatory factors;Cardiovascular events;Adverse Event;Serious Adverse Event; | — |
Countries
China
Contacts
Public ContactXiaomin Chen
The First Affiliated Hospital of Ningbo University
Outcome results
None listed