Acute Gastrointestinal Bleeding
Conditions
Interventions
RM:Using remimazolam for sedation.
PP:Using propofol for sedation.
Sponsors
The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age =18 years, male or female; 2.Admitted to the ICU for gastrointestinal endoscopy or endoscopic treatment; 3.Preoperative American Society of Anesthesiologists (ASA) classification of grade II or above (Grade I: Healthy, well-nourished, normal organ functions; Grade II: Mild systemic disease, no functional limitations, no substantial organ dysfunction; Grade III: Severe systemic disease, limited physical activity, but able to carry out routine activities, with one or more moderate to severe diseases; Grade IV: Severe systemic disease that is a constant threat to life, incapacitated, unfit for any activity without the threat to life; Grade V: A moribund patient who is not expected to survive without the operation; Grade VI: A declared brain-dead patient whose organs are being removed for donor purposes); 4.Light to moderate sedation requirement; 5.Written informed consent provided by the subject or their legally authorized representative.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of severe myasthenia gravis, schizophrenia, severe dementia, and severe depression; 2.Patients with a history of allergic reactions to benzodiazepines or propofol; 3.Patients who are pregnant or breastfeeding; 4.Participants whom the researchers deem unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RASS score;Incidence of intraoperative hypotension;Vital signs;Adverse reactions;MOAA/S score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia wake time;Time to reach target sedation level;Intubation;30-days and 90-days all-cause mortality; | — |
Countries
China
Contacts
Public ContactWu Wen
The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital
Outcome results
None listed