Postpartum depressive episode
Conditions
Interventions
General Practice Group:iTBS on target determined using the "5cm rule"
Sponsors
Yongzhou Zhongke Brain Health and Smart Medical Research Institute
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) Aged between 18 and 45 years, within 4 weeks after childbirth; (2) Outpatient or inpatient participants with an Edinburgh Postnatal Depression Scale (EPDS) score of = 9; (3) Education level of junior high school or above, no language communication barriers, able to cooperate with assessments and treatment, and willing to sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients who have a current or past diagnosis meeting the following DSM-5 criteria: organic mental disorders, schizophrenia, schizoaffective disorder, bipolar disorder, intellectual disabilities, dementia, other cognitive disorders, alcohol or substance dependence, and Axis II disorders including personality disorders. (2) Participants currently enrolled in another clinical trial, unwilling, or unable to complete the full course of this trial. (3) Patients with comorbid depressive or anxiety disorders secondary to physical illnesses such as epilepsy, cardiovascular diseases, pheochromocytoma, hyperthyroidism, or spontaneous hypoglycemia. (4) Contraindications to magnetic resonance imaging (MRI) scans (some special populations cannot/should not/need to be cautious when undergoing MRI examinations, such as patients with implanted cardiac pacemakers, patients with aneurysm clips after craniocerebral surgery, patients with ferromagnetic implants, patients with artificial metallic heart valves after cardiac surgery, patients with alloy prostheses or metal joints, patients with insulin pumps or neurostimulators, etc.). (5) Contraindications to TMS treatment (patients with metal objects in the cranial cavity, patients with cardiac pacemakers, patients with cochlear implants, patients with increased intracranial pressure are not suitable for rTMS treatment; patients with a history of epilepsy or a family history of epilepsy are prohibited from receiving high-frequency strong stimulation). (6) Previous receipt of physical treatments such as electroconvulsive therapy or TMS treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage Change in the Hamilton Rating Scale for Depression (HAMD-17); | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage Change in the Hamilton Rating Scale for Depression (HAMD-17);Percentage Change in the Hamilton Rating Scale for Depression (HAMD-17);Cognition;Brain structural and functional connectivity; | — |
Countries
China
Contacts
Public ContactYanyan Tang
The Central Hospital of Yongzhou
Outcome results
None listed