Anesthesia induction intubation
Conditions
Interventions
Group A:cypofol 0.2mg/kg+ afentanil 25ug/kg
Group B:cypofol 0.2mg/kg+ afentanil 75ug/kg
Group C:cyclopofol 0.3mg/kg+ Afentanil 50ug/kg
Group D: cypofol 0.4mg/kg+ afentanil 25ug/kg
Group E: cypofol 0.4mg/kg+ afentanil 75ug/kg
Sponsors
Shanghai Fourth People's Hospital affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. The age of 18 to 45 years old, any gender, BMI 18.5-24; 2. The marked anesthesia surgery, patients with tracheal intubation; 3. ASA I - II level; 4. After appropriate preoperative preparation of hospitalized patients with emergency; 5. Voluntary and signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Chronic pain, long-term use of analgesics, spirit system drugs (including opioid, NSAIDs, town of static, antidepressants), alcohol abuse; 2. The preoperative liver and kidney function (AST, ALT, BUN, Cr) abnormal ones; 3. Always has a history of abnormal anesthesia; 4. Merge other serious organ dysfunction, coronary heart disease, severe arrhythmia, cerebrovascular accident, heart failure, history of poorly controlled diabetes mellitus, history of diseases of the immune system; 5. Suffering from hypertension and poorly controlled, or home systolic blood pressure > 180 MMHG or diastolic blood pressure > 100 MMHG. 6. Is expected to be difficult airway. 7. The patients with allergic to soy or test drug; 8. Patients with shock; 9. Moderately severe COPD patients; 10. Pregnant women or mothers; 11. Participated in other drug test within three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia induction time of intubation conditions required for medication; | — |
Secondary
| Measure | Time frame |
|---|---|
| The immediate intubation, 1, 2, 5, 10 min after intubation blood pressure, heart rate, the BIS, damage index, maximum heart rate, blood pressure, and damage index;;Patients with eyelash reflex disappearing time and BIS value;;During intubation in patients with tears, choking cough, incidence of glottis closure;Anesthesia induction time of intubation condition and BIS value;Induced drug use and supply quantity and the total number of times;Induced ephedrine, YiSiLuo, monica, ground, atropine usage and dosage; | — |
Countries
China
Contacts
Public ContactLize Xiong
Shanghai Fourth People's Hospital affiliated to Tongji University
Outcome results
None listed