Effects of different crystalloid and colloid on plasma colloid osmotic pressure and postoperative condition during hepatectomy

Effects of different crystalloid and colloid on plasma colloid osmotic pressure and prognosis in perioperative goal oriented fluid management of hepatectomy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300074177

Enrollment

Unknown

Registered

2023-08-01

Start date

2021-08-09

Completion date

Unknown

Last updated

2023-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic hepatectomy

Interventions

A:crystalloid:colloidal=2:1

B:crystalloid:colloidal=1:1

C:crystalloid:colloidal=1:2

Eligibility

Sex/Gender

All

Age

25 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. age 25-75 years. 2. American Society of Anesthesiologists (ASA) physical condition classification 1-3. 3. Child classification A-B. 4. first laparoscopic partial hepatectomy. 5. ethical, patients volunteered for the trial and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Obese patients (BMI>30kg/m2); 2. Patients with severe chronic obstructive pulmonary disease (COPD severity scale 3 or 4), lung infections, severe or uncontrolled bronchial asthma, bronchiectasis, chest malformations, and intrathoracic diseases such as mediastinal and thoracic tumors; 3. Patients with severe heart disease or acute coronary syndrome, persistent ventricular tachyarrhythmias in NYHA grade 3 or 4; 4. Non-first-time hepatectomy patients had cirrhosis with Child grade C, combined with endoscopic esophagogastric varices (red sign), ascites, portal hypertension, hyperplenism, and uncorrected hypoalbuminemia before surgery; 5. Patients with acute and Chronic glomerulonephritis, nephrotic syndrome, Chronic Kidney Diseases (CKD); 6. Patients with severe neuromuscular diseases such as myasthenia gravis and periodic paralysis; 7. Patients with radiotherapy and chemotherapy; 8. Patients who are prohibited from atropine, such as glaucoma, prostatic hypertrophy and atropine allergy, 9. Contraindications in the use of succinyl gelatin.

Design outcomes

Primary

Measure	Time frame
Plasma colloid osmotic pressure;	—

Secondary

Measure	Time frame
ALT;AST;TBIL;ALB;Cr;BUN;PT;APTT;PLT;pH;pCO2;PaO2/FiO2;Glu;Lac;BE;SBP;DBP;MAP;HR;RR;SpO2;CVP;PPV;crystalloid;colloidal;urine volume;Bleeding volume;Sodium bicarbonate injection volume;Total infusion volume;Intraoperative drug combinations;Postoperative complications;Length of hospitalization;Duration of surgery;	—

Countries

China

Contacts

Public ContactBingyuan He; Mingqing Peng

Yongchuan Hospital of Chongqing Medical University

315747391@qq.com+86 187 2310 4291

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026