Sinus Tachycardia
Conditions
Interventions
Anisodamine hydrobromide treatment group (Group N):Anisodamine hydrobromide antagonizes the bradycardic effect of neostigmine
Atropine control group (Group N): Atropine antagonizes the bradycardic effect of neostigmine
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years old, any sex, ASA classification Level I-II; 2. Participants undergoing surgical procedures under general anesthesia with tracheal intubation; 3. Electrocardiogram in sinus rhythm; 4. Ethical, voluntary and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Participants with obvious abnormalities in preoperative electrocardiogram, inability to communicate normally, and inability to describe symptoms; 2. The electrocardiogram has arrhythmias (such as supraventricular arrhythmias or ventricular arrhythmias); 3. Previous history of severe cardiovascular disease or cardiac surgery; 4. History of neurological and urinary system diseases, liver and kidney diseases, and Sjogren's syndrome; 5. History and medical history of antiepileptic drugs, antiarrhythmic drugs, and other drugs known to affect electrocardiogram; 6. Severe electrolyte disorder; 7. Contraindications to neostigmine, anisodamine, and atropine; 8. Other possible reasons that may affect the study or reject participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions (arrhythmia, thirst, dysuria); | — |
Countries
China
Contacts
Public ContactCao Lijun
The Second Xiangya Hospital of Central South University
Outcome results
None listed