supratentorial tumor resection
Conditions
Interventions
Fopropofol group:The induction and maintenance of anesthesia were performed with fopropofol disodium.
Propofol group:The induction and maintenance of anesthesia were performed with propofol.
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: If any of the following is "no", the patient cannot participate in the trial: (1) Patients undergoing supratentorial tumor resection; (2) Age 18-65 years old, gender unlimited; (3) American Society of Anesthesiologists (ASA) : Level I-III; (4) Body mass index (BMI) : 18.5~30 kg/m2; (5) Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: If any of the following is "Yes", this patient cannot participate: (1) Chronic users of analgesics, psychotropic drugs (including opioids, NSAIDs, sedatives, antidepressants), and alcohol abusers; (2) Patients with serious heart, brain, lung, liver, kidney and other important organ dysfunction and electrolyte abnormalities before surgery; (3) previous history of poorly controlled hypertension or ischemic heart disease; (4) Patients with a history of intraoperative drug allergy; (5) Patients with prolonged QT interval indicated by preoperative electrocardiogram; (6) History of peripheral arterial and/or cerebrovascular diseases; (7) Patients taking anticoagulant drugs such as aspirin or with coagulation dysfunction; (8) Estimated amount of surgical bleeding > 1000ml patients; (9) Patients with preoperative cognitive dysfunction determined by MMSE scale; (10) Pregnant and lactating women; (11) Have participated in other drug trials within three months; (12) Other patients deemed unsuitable for this study by investigators;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Cardiac output;stroke volume variation;BIS value;The occurrence of intraoperative hypertension; hypotension;The occurrence of intraoperative tachycardia;The occurrence of intraoperative bradycardia;The time required for BIS to fall to 40-60 after induction of anesthesia;Intraoperative drug use;Spontaneous breathing recovery time, eye opening time, extubation time during the recovery period;Aldrete score 30 minutes after extubation;Anesthesiologist, surgeon, and patient satisfaction with the effect of anesthesia;The occurrence of perioperative adverse reactions;Postoperative cognitive function assessment;NRS pain scores after surgery;Glasgow scores after surgery; | — |
Countries
China
Contacts
Public ContactWang E
Xiangya Hospital, Central South University
Outcome results
None listed