spinal metastases patients with iron deficiency anemia after operation
Conditions
Interventions
The treatment group:Iron isomaltoside on the third postoperative day (according to the recommendations of the drug manufacturer), and the maximum dose of iron isomaltoside was limited to 20mg/Kg.
The control group:Ferrous succinate tablets 200mg bid on the third day after operation, a total of 400mg per day, continuous oral administration for 28 days.
Sponsors
Shanghai Changzheng Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Written informed consent can be signed. 2. Age =18 years old. 3. Malignant tumors confirmed by pathology, and spinal metastasis was suggested by X-ray, CT or magnetic resonance imaging. 4, At least one spinal metastatic lesion requiring surgical intervention: accompanied by malignant pain, spinal instability, spinal cord compression. 5. The function of organs other than organs involved by malignant tumor was good, and the Eastern Cooperative Oncology Group (ECOG) score was 0-2. 6. The expected survival time was =3 months. 7.preoperative hemoglobin =9g/dL, postoperative hemoglobin 7-11g/dL or preoperative and postoperative hemoglobin difference > 2g/dL. 8. drainage =200ml/ day.
Exclusion criteria
Exclusion criteria: 1. Spinal metastases from primary spinal tumors or malignant tumors not confirmed by pathology. 2. Hematological malignancies involving the spine: leukemia, lymphoma, multiple myeloma, etc. 3. Iron metabolism disorders, hemolytic anemia. 4. Allergic diseases and history of iron drug allergy. 5. Liver cirrhosis, alanine aminotransferase or aspartate aminotransferase > 80IU/L. 6. Systemic lupus erythematosus, rheumatic diseases. 7. Infectious diseases. 8. History of blood transfusion within 1 month, pregnancy, radiotherapy and chemotherapy. 9. Refuse to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hemoglobin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Reticulocyte count;Reticulocyte hemoglobin content;Serum ferritin;Transferrin saturation;Serum phosphorus; | — |
Countries
China
Contacts
Public ContactBo Li
Shanghai Changzheng Hospital
Outcome results
None listed