Effect and mechanism of dexmedetomidine and ulinastatin combined with healthy lateral position on pulmonary complications in patients with pulmonary lobectomy under thoracic microscope

Effect and mechanism of dexmedetomidine and ulinastatin combined with healthy lateral position on pulmonary complications in patients with pulmonary lobectomy under thoracic microscope: A prospective, randomized, controlled study - /

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300074039

Enrollment

Unknown

Registered

2023-07-27

Start date

2022-09-06

Completion date

Unknown

Last updated

2023-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pulmonary complications

Interventions

Control:Dexmedetomidine and ulinastatin were not used and the patient remained in a supine position

L-P:Dexmedetomidine and ulinastatin were not used and a healthy lateral position was maintained

DEX-UTI:Use dexmedetomidine and ulinastatin and remain in a supine position

DU-LP:Use dextrome and ulinastatin and maintain a healthy lateral position

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) 2022.04-2023.04 patients with thoracoscopic pulmonary lobectomy; (2) Preoperative ASA score of grade I-III; (3) Grade I-II cardiac function; (4) Patient's informed consent.

Exclusion criteria

Exclusion criteria: (1) Mental illness or poor compliance, unable to complete the experiment; (2) Acute lung infection in the last 4 weeks; (3) History of intrathoracic surgery, pneumothorax, bronchiectasis, tuberculosis, fibrosis, etc.; (4) Poor single lung ventilation, blood oxygen saturation less than 87% for more than 10 minutes; (5) Use of hormone drugs before surgery (within 6 months); (6) Pleural effusion existed before surgery; (7) The operation time is less than 1 hour or more than 4 hours; (8) Fatal complications such as massive bleeding and anaphylactic shock occurred during/after the operation; (9) conversion to thoracotomy; (10) ulinastatin and dexmedetomidine allergy; (11) Patients with severe conduction block; (12) Patients with severe hepatic and renal insufficiency.

Design outcomes

Primary

Measure	Time frame
Atelectasis area;The incidence of lung infection;Inflammatory index;arterial blood gas analysis;oxygenation index;	—

Secondary

Measure	Time frame
Postoperative pain score;Antibiotic usage;Length of patient stay/cost;Semiannual mortality rate;	—

Countries

China

Contacts

Public ContactZhongmeng Lai

Union Hospital affiliated to Fujian Medical University

angerer1980@163.c0m+86 133 9500 0771

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026