Effect of intraoperative methylene blue on postoperative delirium in elderly patients undergoing joint replacement

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300074038

Enrollment

Unknown

Registered

2023-07-27

Start date

2023-08-01

Completion date

Unknown

Last updated

2023-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Delirium

Interventions

Methylene blue group:The patients in methylene blue group receive continuous intravenous infusion of 2 mg/kg methylene blue diluted with 5% glucose solution into total 50 ml volume within 60 min imme

Control group:The patients in control group receive intravenous infusion of 50 ml of 5% glucose solution within 60 min immediately after anesthetic induction.

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients undergoing joint replacement under general anesthesia; 2. Age = 65; 3. Available for on-site follow-up interviews and willing to complete neuropsychological testing

Exclusion criteria

Exclusion criteria: 1. Preexisted dementia, major depression or other serious mental or neurological disorders ; 2. History of allergy to MB or 6-phospho-glucose dehydrogenase deficiency (favism); 3. Drug or alcohol abuse or recent drug administration that may lead to drug interactions, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs); 4. History of major head trauma; 5. Emergency surgery; 6. Serious medical diseases (ie. heart failure, pulmonary hypertension, respiratory failure, liver and kidney dysfunctions; 7. Severe language, visual or auditory deficiency; 8. Participated in other clinical trials within 3 months; 9. Preoperative Mini-Mental State Examination (MMSE) score, illiterate (i.e., uneducated) MMSE 6 years of education) MMSE < 24 ;

Design outcomes

Primary

Measure	Time frame
Incidence of delirium within 5 days after surgery;	—

Secondary

Measure	Time frame
Duration and severity of delirium and type of delirium;CRSR score 10 minutes and 20 minutes after extubation;Incidence of delayed neurocognitive recovery after surgery(7-30 days);Postoperative pain score;Hospitalization time (from the day of surgery to discharge);	—

Countries

China

Contacts

Public ContactZhang Yueying

Affiliated Hospital of Xuzhou Medical University

zyy0218@126.com+86 180 5226 8602

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026