Metabolic syndrome,bariatric surgery
Conditions
Interventions
Group ND:Dexmedetomidine (1ug/kg) was pumped 10 minutes before induction, then 0.4ug/kg·h was pumped to 20 minutes before the end of surgery, and then 0.2mg/kg Nalbuphine hydrochloride was administere
Group D:Dexmedetomidine (1ug/kg) was pumped 10 minutes before induction, then 0.4ug/kg·h was pumped to 20 minutes before the end of surgery
Group N:20 minutes before the end of the operation, give 0.2mg/kg Nalbuphine hydrochloride
Group C:Give the same volume of physiological saline
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1, Age:18-65 years old 2,BMI=30kg/m2 3,ASA grade II-III 4,Patients who choose to undergo laparoscopic bariatric surgery
Exclusion criteria
Exclusion criteria: 1,Severe cardiovascular disease, chronic renal failure or liver dysfunction 2,Previous upper abdominal surgery 3,History of serious alcoholism, recent use of opioids, and chronic pain 4,Presence of bradycardia, arrhythmia and hypotension 5,Contraindication of nerve block, such as skin infection at or near the puncture site, coagulation dysfunction 6,Allergies to test drug allergy 7,Long term use of corticosteroid or pregnancy 8,Mental or nervous system disease 9,Refusal to sign informed consent form 10,Participate in other clinical trials at the same time
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-40; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;Mean artrial pressure;Perioperative use of propofol and remifentanil;Vasoactive drug usage rate;Consumption of remedial analgesics within 24h;Scoring of restlessness during awakening period;Heart rate;Extubation time;Postoperative first time out of bed activity time;First anal exhaust time;Adverse reaction rate;Discharge time; | — |
Countries
China
Contacts
Public ContactWang Guanglei
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed