Postoperative Delirium
Conditions
Interventions
EXPAREL-group:preoperative fascia iliaca block, EXPAREL 20 mL (266 mg)
Ropivacaine-group:preoperative fascia iliaca block, Ropivacaine 20mL (75mg)
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Elderly patients with hip fracture undergoing elective surgical treatment, including femoral neck fracture, femoral intertrochanteric fracture and femoral fracture above 5 cm below lesser trochanter (generally considered to be 1/3 of the upper femoral shaft). 2. Aged = 65 years. 3. ASA Grade I ~ III. 4. Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: 1. Compound injuries: Merge multiple fractures, such as trauma to areas outside the hip, including the head, chest, pelvis, and limbs. 2. Patients with a history of diagnosed mental illness or currently taking psychotropic medication. 3. Preoperative delirium occurred, or medication for delirium (such as olanzapine and a2 receptor agonists) was considered. 4. Patients with a history of acute cerebral vascular disease (six months of intracerebral or cerebral hemorrhage). 5. Patients without normal communication or with language dysfunction. 6. Patients requiring sedation or who are comatose after surgery because of their condition. 7. Patients with allergies to amide-based local anesthetics. 8. Patients with polycystic ovary syndrome or Wolff Parkinson White syndrome. 9. Second- or third-degree atrioventricular block/sinoatrial node syndrome without pacemakers. 10. Patients with a ventricular rate of <50 beats/min or Q-T prolongation indicated by electrocardiography at admission. 11. Patients with severe liver and kidney dysfunction. 12. Patients who have participated in other clinical studies. 13. Patients with a history of drug addiction or abuse. 14 .Patients with anemia or other conditions requiring blood transfusions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Delirium; | — |
Countries
China
Contacts
Public ContactLi Jinbao
Shanghai General Hospital
Outcome results
None listed