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The clinical efficacy of fosartan, ondansetron and dexamethasone triple antiemetic regimen in patients with high risk of postoperative nausea and vomiting after gynecological laparoscopic surgery and thyroid surgery

The clinical efficacy of fosartan, ondansetron and dexamethasone triple antiemetic regimen in patients with high risk of postoperative nausea and vomiting after gynecological laparoscopic surgery and thyroid surgery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300074020
Enrollment
Unknown
Registered
2023-07-27
Start date
2023-08-01
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative nausea and vomiting

Interventions

SOD group:ondansetron + dexamethasone
FOD group:fosappitan + ondansetron + dexamethasone

Sponsors

Jinan Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective thyroid surgery or gynecological laparoscopic surgery; 2. Apfel score = 3; 3. The duration of anesthesia was more than 2 hours; 4. ASA grade I-II; 5. Aged 18-65 years; 6. Patients voluntarily signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Previous allergy to antiemetic drugs; 2. Arrhythmia, gastrointestinal diseases, diabetes mellitus, obesity (BMI=35 kg/m2); 3. Pregnant, lactating patients or planned pregnancy within one month; 4. Patients treated with antiemetics, systemic steroids and opioids before surgeryand less than5 half-lives, or any other drugs known to cause vomiting; 5. Chronic pain diseases.

Design outcomes

Primary

MeasureTime frame
the incidence of PONV;—

Secondary

MeasureTime frame
the incidence of postoperative adverse reactions;Effect on postoperative pain;vital signs;Patient satisfaction score;—

Countries

China

Contacts

Public ContactWenying Chi

Jinan Central Hospital

wenyingchi1988@163.com+86 186 5455 7772

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026