The effect of ABCDE bundle management combined with extracorporeal diaphragmatic pacemaker and respiratory training on the diaphragm in patients with invasive ventilator

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300074013

Enrollment

Unknown

Registered

2023-07-27

Start date

2023-08-01

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU critically ill patients with invasive ventilators

Interventions

intervention group:External diaphragm pacemaker and breathing training

control group:Regular rehabilitation training

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Age = 18 years, invasive respiratory ventilation over 24 to 48 hours, P>40 bpm, or P<120 bpm; systolic blood pressure (SBP) = 90 or =180 mmHg, or/and diastolic blood pressure (DBP) = 110 mmHg, mean arterial pressure (MBP) =65 mmHg or =110 mmHg; respiratory rate= 35 breaths per minute; Oxygen saturation = 90%, mechanical ventilation inspired oxygen concentration (FIO2) = 60%, positive end-expiratory pressure (PEEP) = 10cmH2O; In the extended life support phase, low-dose vasoactive agents support, dopamine= 10 µg/kg/min or norepinephrine/epinephrine =0.1 µg/kg/min.

Exclusion criteria

Exclusion criteria: newly started vasopressors, or increasing the dose of vasopressors.

Design outcomes

Primary

Measure	Time frame
Diaphragm thickness and mobility;Blood Gas Analysis;	—

Secondary

Measure	Time frame
Blood routine;blood biochemical;	—

Countries

China

Contacts

Public ContactLiu Hongwei

The Second Hospital of Shandong University

15153169176@163.com+86 176 6008 3979

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026