Diminished ovarian reserve
Conditions
Interventions
study group:Administer growth hormone 2IU/d from the menstrual cycle before ovulation induction to the day of OocytePickUp
control group:no use of growth hormone
Sponsors
the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Eligibility
Sex/Gender
Female
Age
20 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1. Chinese women aged < 38years; 2. Diagnosed as a patient with diminished ovarian reserve according to the 2011 Bologna criteria; 3. Those who receive Assisted Reproduction Treatment at our center.
Exclusion criteria
Exclusion criteria: 1. One or both spouses have chromosomal abnormalities; 2. The woman has a clear family history of hereditary premature ovarian failure or hereditary factors;Existence of uterine abnormalities such as uterine malformations (single horn uterus, mediastinal uterus, double uterus, double horn uterus), uterine fibroids, submucosal fibroids, or uterine adhesions; 3. Contraindications for assisted pregnancy treatment or application of growth hormone: liver diseases or liver function abnormalities (abnormal serum liver enzyme indicators) with unclear etiology; Kidney disease or abnormal renal function; Severe anemia; Diagnosed heart disease; History of malignant tumors such as cervical cancer, endometrial cancer or breast cancer; Poor blood sugar control; Thyroid dysfunction; 4. Having serious internal and external complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of high-quality embryos of D3;High quality embryo rate of D3;Number of retrieved oocytes;Biochemical pregnancy rate;Embryo implantation rate;Abortion rate;live birth rate; | — |
Countries
China
Contacts
Public ContactWu Dandan
the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Outcome results
None listed