pediatric Crohn's disease
Conditions
Interventions
1:modified Jiangnan diet
2:exclusive enteral nutrition
Sponsors
Children's Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
4 Years to 18 Years
Inclusion criteria
Inclusion criteria: Children aged 4 to 18 years; Diagnosed Crohn's disease according to expert consensus for diagnosis and management of pediatric IBD which is published in 2019 in China; Mild to moderate active Crohn's disease (PCDAI ranged from 11 to 45); Patient receiving the following treatments were eligible: 5-aminosalicylates (if the dose remained constant for 4 weeks before the screening visit); corticosteroids (prednisone, prednisolone, or budesonide) at stable dose for 3 weeks; azathioprine and 6-mercaptopurine can start with diet therapy; methotrexate (stable dose for 8 weeks) ; infliximab or adalimumab (in maintenance period).
Exclusion criteria
Exclusion criteria: Biologics start in 4 weeks after exclusive enteral nutrition therapy or modified Jiangnan diet therapy; History of bowel resection; Bowel stricture, perforation, perianal fistula or abscess; Enrolled in other clinical trial in 6 months; be considered not suitable for the study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adherence;clinical remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life;CDEIS; | — |
Countries
China
Contacts
Public ContactLUO Youyou
Children's Hospital, Zhejiang University School of Medicine
Outcome results
None listed