Tic Disorders
Conditions
Interventions
Healthy control group:N/A
Tic disorder group:If patients with tic disorder require medication treatment, oral administration of Tiapride hydrochloride is the first choice for treatment
Sponsors
Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology
Eligibility
Sex/Gender
All
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: Two groups of people need to be included, and the diagnostic inclusion criteria are: Healthy control group: 1. Age between 3 and 12 years old; 2. During the physical examination, inquire about the medical history and confirm that the patient has been in good health and has no special dietary habits; 3. The guardians of the children fully understand the research content and are willing to sign the informed consent. Tic disorder group: 1. Conform to the diagnostic criteria of western medicine for Tic Disorders in children.The diagnostic criteria refer to the fifth edition of the diagnostic and Statistical Manual of Mental Disorders(DSM-5)issued by the American Psychiatric Association; 2. Age between 3 and 12 years old; 3. The guardians of the children fully understand the research content and are willing to sign the informed consent.
Exclusion criteria
Exclusion criteria: Healthy control group: 1. Previous neurological or mental illnesses such as tic disorder, epilepsy, and childhood emotional disorders; 2. Stress states such as infection and trauma before blood collection; 3. Those who have a history of infectious diseases in the past two weeks. Tic disorder group: 1. Individuals with other mental illnesses or delayed intellectual and motor development; 2. Those who take other psychotropic drugs; 3. Those who have a history of infectious diseases in the past two weeks; 4. Children with blood pressure lower than the normal age group or the mean of the same sex group+2 standard deviations; 5. Not suitable for joining; 6. Those who have no record of diagnosis and treatment during follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Yale Global Tic Severity Scale;Neurotransmitter;Thiopride blood concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment Emergent Symptom Scale; | — |
Countries
China
Contacts
Public ContactLiu Zhisheng
Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology
Outcome results
None listed