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Prediction of acute and chronic pain after non-cardiac surgery and establishment of pain prediction model based on NLRP3 inflammasome signaling pathway

Prediction of acute and chronic pain after non-cardiac surgery and establishment of pain prediction model based on NLRP3 inflammasome signaling pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300073958
Enrollment
Unknown
Registered
2023-07-26
Start date
2023-08-01
Completion date
Unknown
Last updated
2023-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperation pain

Interventions

Case series:No intervention

Sponsors

National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18-70 years old, gender unlimited; ASA Grade I - III; Obtain informed consent from patients and their families.

Exclusion criteria

Exclusion criteria: Patients with inflammatory diseases; Patients who have received surgical treatment within the last 30 days; Pregnant women; Patients with kidney disease; Long-term use of psychotropic drugs such as sedatives or antidepressants; Language comprehension difficulties, mental illness, inability to go to the hospital for follow-up visits, etc. Have taken another investigational drug or participated in another clinical trial in the 3 months prior to study enrollment; Preoperative radiotherapy or chemotherapy; Other conditions considered inappropriate to include in this study.

Design outcomes

Primary

MeasureTime frame
postsurgical pain;mRNA expression of NLRP3 inflammasome in peripheral blood;;;

Secondary

MeasureTime frame
inflammatory factor;

Countries

China

Contacts

Public ContactYan Tao

National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

blizzardyt@163.com+86 185 0087 9007

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026