Parkinson's Disease
Conditions
Interventions
deep brain stimulation group:N/A
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
40 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) According to the diagnostic criteria of Parkinson's disease in China (2016 edition); (2) aged between 40 and 80 years old; (3) Mini-Mental State Examination score greater than 21; (4) There was no change in drug therapy during the four weeks before surgery.
Exclusion criteria
Exclusion criteria: (1) History of drug addiction, brain injury, or mental illness; (2) inability to complete MRI scan due to significant tremor symptoms or metal implants in the body; (3) Patients could not complete the relevant cognitive and MRI examinations after 12 hours of drug withdrawal, or take drugs that affect cognitive function such as antane.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| UPDRS-III(Unified Parkinson's Disease Rating Scale-III); | — |
Secondary
| Measure | Time frame |
|---|---|
| UPDRS-V(Unified Parkinson's Disease Rating Scale-V);HAMD(Hamilton Depression Scale);HAMA(Hamilton Anxiety Scale);MMSE (Mini-mental State Examination);MoCA (Montreal Cognitive Assessment);PDQ-39 (The Parkinson's Disease Questionnaire-39);NMSS(Non-motor Symptom Assessment Scale);PDSS (Parkinson's Disease Sleep Scale);PAC-SYM(Patient Assessment of Constipation symptom);education years;LED (Levodopa equivalent dose);Freezing gait score;White matter lesions;Frontal lobe function rating scale; | — |
Countries
China
Contacts
Public ContactChaoshi Niu
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed