Breast Cancer
Conditions
Interventions
Opioid-free group:Intravenous lidocaine 2mg/kg at induction, intravenous dexmedetomidine 1µg/kg, preoperative diamond intercostal block with ropivacaine, intraoperative continuous pumping of dexmedeto
Control group:Conventional general anesthesia with opioids
Sponsors
Weifang City People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients aged 20-70 years, ASA grade I-II, undergoing modified radical mastectomy for breast cancer
Exclusion criteria
Exclusion criteria: Patients with BMI > 26, history of local anesthetic allergy, severe respiratory, renal or hepatic disease, preoperative opioid use and history of psychiatric disorders. Patients with severe hypotension (mean arterial pressure [MAP] < 60mmhg) or bradycardia (heart rate [HR] < 40bpm), cardiac arrhythmias or urticaria caused by intraoperative infusion of lidocaine and dexmedetomidine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score;Time of first postoperative venting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting;Extubation time;Intraoperative hemodynamics; | — |
Countries
China
Contacts
Public ContactBao Lang
Weifang City People's Hospital
Outcome results
None listed