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A correlation study of cognitive impairment about serum adiponectin, cAMP/PKA/AQP4-BDNF and perioperative god in elderly patients under general anesthesia

A correlation study of cognitive impairment about serum adiponectin, cAMP/PKA/AQP4-BDNF and perioperative god in elderly patients under general anesthesia

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300073901
Enrollment
Unknown
Registered
2023-07-25
Start date
2023-07-14
Completion date
Unknown
Last updated
2023-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative neurocognitive disorder

Interventions

Thoracic surgery group:No

Sponsors

The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 85 Years

Inclusion criteria

Inclusion criteria: Patients ranged in age from 60 to 85 years old. Complete clinical data; The ASA grade was ?~?, and the surgical site was lung. Preoperative MMSE score was > 26 points.

Exclusion criteria

Exclusion criteria: Patients with uncontrolled diseases such as severe cardiac, liver and renal dysfunction or malignant tumor before operation; Patients with neurological or psychiatric history; Patients who take hypnotics, narcotic analgesics, antidepressants and anti-anxiety drugs for a long time; Patients with coagulation dysfunction; Poor compliance or other reasons unable to cooperate with researchers.

Design outcomes

Primary

MeasureTime frame
Serum adiponectin;

Secondary

MeasureTime frame
Serum cAMP;Serum PKA;Serum AQP4;Serum BDNF;

Countries

China

Contacts

Public ContactXie Haihui

The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospita

xhh900@163.com+86 137 9058 8393

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026