mild cognitive impairment
Conditions
Interventions
intervention group:exercise, cognitive intervention, and health education
active control group 1:exercise and health education
active control group 2:cognitive intervention and health education
passive control group:health education
Sponsors
Peking University
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Participants aged between 60 and 75 years old; 2. Participants were diagnosed as mild cognitive decline according to the Petersen criteria (Participants complained of memory loss for more than three months, which need to be proved by others. Objective memory decline that does not match age and educational level, and the overall cognitive function is basically normal. MMSE>17 for illiterate, MMSE>20 for primary school, MMSE>24 for junior high school and above. The score of GDS was 2-3. ADL was basically normal and the score in ADL was less than 14. No dementia (CDR=0.5)); 3. Participants have sedentary lifestyle in daily life; 4. Participants can understand the complete the intervention plan and the outcome assessment scales; 5. Participants sign an informed consent form and promise to have time to participate and complete the plan during the research; 6. Participants are not engaging in another intervention project currently; 7. Participants are accompanied by at least one family member or caregiver during the intervention; 8. Participants are living in the intervention area during the research.
Exclusion criteria
Exclusion criteria: 1. Participants developed nervous system diseases or orthopedic comorbidities and cannot conduct resistant training safely; 2. Participants has contraindications to aerobic exercise including confirmed heart disease and confirmed diabetes with poor control effect; 3. Participants use ß - Receptor blockers and/or antipsychotic medications; 4. Participants developed major depression, schizophrenia, and any form of mental illness or were confirmed severe neurological disorders in the previous year; 5. Participants developed Alzheimer's disease, infections of the central nervous system, post-traumatic dementia, toxic encephalopathy, metabolic encephalopathy, Huntington's disease, multiple sclerosis or Parkinson's disease before memory loss; 6. Participants were unable to complete simple smartphone operations; 7. There was no smartphone or Internet at home; 8. Participants did not have free time over 10% of 3 months; 9. Participants did not pass the health screening questionnaire before exercise training.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| global cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Activities of daily living;Quality of life;Fatigue;Frailty;Body function, ADL;Intrinsic capacity;Sleep quality; | — |
Countries
China
Contacts
Public ContactYanan Luo
Department of Global Health, School of Public Health, Peking University
Outcome results
None listed