COVID-19 pneumonia
Conditions
Interventions
Experimental group:Nebulized inhalation of heparin, acetylcysteine, budesonide and ipratropium bromide
Control Group:Routinely treatment for COVID-19
Sponsors
Army Medical Center (Daping hospital), Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-80 years old; 2. Medium and severe patients with novel coronavirus who meet the diagnostic criteria of the Diagnosis and Treatment Protocol for novel Coronavirus infection (trial version 10); 3. Onset time < 1 month; 4. Chest CT showed the characteristic manifestations of COVID-19 pneumonia: multiple small spot shadows and interstitial changes, especially in the outer band of the lung; Multiple ground glass and infiltration shadows in both lungs; In severe cases, lung consolidation occurs; 5. Ability to receive aerosol inhalation therapy; 6. Agree to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Symptoms of hemoptysis; 3. Allergic/intolerant to experimental drugs; 4. Severe respiratory failure requiring invasive mechanical ventilation; 5. The presence of tracheotomy and other conditions can not cooperate with atomization; 6. Patients with underlying diseases with severe interstitial lung disease (lung function DLCOS < 50% of expected value); 7. Patients with coagulation dysfunction (meet any condition) : Six items of coagulation show hypocoagulation state; Platelet < 50×10^9/L; Bleeding from the skin or other organs; 8. Patients with pulmonary edema complicated by heart failure; 9. Other life-threatening complications: severe liver and kidney damage, uncontrolled malignant tumors, etc.; 10. Patients participating in other clinical trials; 11. Other reasons are not considered appropriate for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of lung lesion resolution on the eighth day in hospital; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement rate of oxygenation index;Oxygen saturation of the finger pulse;Hospital stays;Cost of hospital admission; | — |
Countries
China
Contacts
Public ContactGuoqiang Cao
Army Medical Center (Daping hospital), Army Medical University
Outcome results
None listed