early onset sepsis
Conditions
Interventions
Gold Standard:The diagnostic criteria for early-onset sepsis (EOS) include meeting one or more of the following criteria: 1) Premature rupture of membranes (=18 hours) with positive culture confirming
2) Clinical symptoms including respiratory distress (retractions or apnea), tachycardia (heart rate > 160 bpm), bradycardia (heart rate 3s), neurological impairment (seizures, irritability, or lethar
3) Positive blood or cerebrospinal fluid culture, and two or more positive results from routine laboratory tests (WBC 25×10^9/L, CRP > 5 mg/L, immature neutrophil to total neutrophil ratio (I/T ratio
Index test:HBP, blood routine, hypersensitive CRP, PCT, blood culture
Sponsors
Wenling Maternal and Child Health Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Experimental group: High-risk newborns delivered in our hospital, including preterm infants, infants requiring resuscitation at birth, infants born to mothers with chorioamnionitis (CAM) or maternal fever during labor, infants with Group B Streptococcus (GBS) colonization or bacteriuria, infants with a history of GBS infection, infants with premature rupture of membranes (PROM) lasting =18 hours, infants with contaminated amniotic fluid, and infants presenting symptoms suggestive of bacterial infection, such as respiratory distress, seizures, hypotension, poor feeding tolerance, decreased intake, vomiting, reduced movement, delayed jaundice regression, body temperature maintained below 35°C or fever (body temperature > 37.5°C). Control group: Healthy volunteers.
Exclusion criteria
Exclusion criteria: Experimental group:High-risk newborns whose families refuse hospitalization, and newborns with congenital malformations and other severe life-threatening conditions, including congenital heart disease, metabolic disorders, chromosomal abnormalities, etc. Control group:newborns with congenital malformations and other severe life-threatening conditions, including congenital heart disease, metabolic disorders, chromosomal abnormalities, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBP;PCT;CPR;ROC curve;Sensitivity;specificity; | — |
Countries
China
Contacts
Public ContactXiyang Chen
Wenling Maternal and Child Health Care Hospital
Outcome results
None listed