Ventilator-associated Pneumonia (VAP)
Conditions
Interventions
Rreatment group:Inhaled atomized amphotericin B
Control group:Inhalated sterilizing water for injection
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Sign the informed consent form (for those without the ability to sign, the entrusted party shall sign on behalf of them) and promise to follow the research procedures and cooperate in the implementation of the entire process of research 2. Age = 18 and = 85 3. Adult patients with mechanical ventilation = 72h 4. For patients with candida detected in the airway twice in a row (the inspection interval is more than 1 day), the inspection method is microscopic inspection or culture, and spores or mycelium detected can be considered as colonization 5.The time interval between enrollment and intervention treatment shall not exceed 24 hours
Exclusion criteria
Exclusion criteria: 1.Unable to obtain the informed consent of the subject, family members or authorized agents; 2.Patients with mechanical ventilation1 mg/kg) steroid drugs or use of other immunosuppressive drugs; 6.Suffer from ventilator associated pneumonia (VAP) recently (within 2 weeks); 7.Have received intravenous amphotericin B or nebulization (NAB) treatment within one month; 8.Patients receiving systemic antifungal treatment or more than 72h antifungal treatment within one week; 9.Subjects suffered from severe granulocytopenia (white blood cell count less than 500/mm3); 10.HIV infection; 11.BMI less than 15kg/m2; 12.Subjects are undergoing other clinical studies; 13.Pregnancy or breastfeeding; 14.Serious lung disease requires ECMO support; 15.Estimated survival time of ICU < 48h;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of VAP within 28 days;Mechanical ventilation time;The proportion and time of candida decolonized within 28 days; Organ function scores improved during follow-up (SOFA and APACHEII scores);Successful rate of ventilator weaning (28 days);ICU mortality;length of ICU stay;Incidence of candidiemia at 28 days;90-day all-cause mortality rate; | — |
Countries
China
Contacts
Public ContactDechang Chen
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed